How A2CT hydrates
Keeping cells properly hydrated is essential to their healthy functioning. Electrolytes play a vital role in cellular hydration because water is pulled into cells through osmosis (passive transport) to buffer their ionic charge. When not enough ions from electrolytes are present, water leaves the cell.
The electrolytes themselves require active transport. Active transport uses a transport protein and energy source to move nutrients through cell membranes against a concentration gradient. Both glucose and amino acids initiate the active transport of electrolytes. Unlike glucose, however, amino acid-enabled product formulations achieve whole-body hydration, which includes hydration of all three fluid compartments.
To hydrate cells, water and electrolytes must pass from the small intestine through the blood (vascular hydration), fill the space between cells (interstitial hydration) and enter the space inside cells (intracellular hydration).
Sodium actively transports glucose into the vascular region, but here the glucose and sodium molecules separate. The cells lining the blood vessels transport only glucose into the adjacent tissue spaces (interstitial compartment) and adjacent cells (intracellular compartment). The sodium remains in the vascular region.
Unlike glucose, amino acids do not uncouple from electrolytes in the blood. Rather, they transport electrolytes and fluids through the cells lining the blood vessels into the interstitial and intracellular regions for optimal whole-body hydration. This restores homeostasis and moderates the impact of stress on the body.
How A2CT rebuilds
Entrinsic Health Solutions formulations help restore gut structures. Research on these formulations has revealed that A2CT Technology supports the growth and restoration of intestinal absorptive mechanisms, including villi.
In a healthy environment, villi are regenerated every 5-7 days. If the villi are blunted—as they are in malnourished children, oncology patients and undernourished elderly—less surface area exists, which dramatically reduces electrolyte and nutrient absorption.
In addition, glucose and some nutrients are absorbed in the tips of the villi, so blunted villi are unable to absorb these nutrients. Villi naturally replenish themselves, but in environments where villi are continually blunted, gastrointestinal toxicity, environmental enteric dysfunction and malnutrition can occur. The combination of amino acids in A2CT has been shown to nourish the villi and improve: number of villi, villus height and crypt cell count.
By repairing villi and crypt health, A2CT Technology helps rebuild the body’s absorptive mechanisms, increasing its ability to take in nutrients as well as water.
How A2CT protects
Amino acids help maintain a healthy mucosal lining, which provides a protective barrier to inhibit the flow of ingested matter to other parts of the body. Dehydrated cells shrink and break down some of the proteins that hold cells together, which can result in increased paracellular permeability, leading to bacterial translocation. This in turn leads to intestinal discomfort and reduced function.
By hydrating not only the vascular, but also the interstitial and intracellular compartments, A2CT Technology supports healthy barrier function which helps reduce paracellular permeability, helps maintain healthy inflammation levels, and supports healthy immune function.